Edorium Journal of

Tumor Biology

 
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Original Article
 
The polymorphism of G protein β3 subunit C825T and cancer risk: A Meta-analysis
Yaxuan Zhang1, Dongfeng Han1, Wenjin Wei1, Xiupeng Xu1, Rui Zhang1, Qingsheng Dong1, Xiefeng Wang1, Junxia Zhang2, Yingyi Wang2, Ning Liu3
1Marster, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China.
2Doctor, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China.
3Professor, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China.

Article ID: 100002T09YZ2015
doi:10.5348/T09-2015-2-OA-1

Address correspondence to:
Ning Liu
300 Guangzhou Road, NanJing City
JiangSu province, PR
China. 210029
Email: liuning0853@126.com

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How to cite this article
Zhang Y, Han D, Wei W, Xu X, Zhang R, Dong Q, Wang X, Zhang J, Wang Y, Liu N. The polymorphism of G protein β3 subunit C825T and cancer risk: A Meta-analysis. Edorium J Tumor Bio 2015;2:1–10.


Abstract
Aims: In previous studies, G protein β3 subunit (GNB3) C825T polymorphism was reported to have association with various cancers. However, the results were inconclusive, this meta-analysis was performed to investigate the association between GNB3 gene polymorphism C825T and cancer risk.
Methods: A comprehensive search in PubMed database was conducted for studies by March, 2014. Meta-analysis was performed using the STATA 11.0 software. Cancer risk associated with GNB3 C825T was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs).
Results: Nine independent studies including 2246 cancers and 3851 controls were included in our meta-analysis. Our results indicated that GNB3 C825T was not associated with the risk of cancer for alleles T vs C [odd ratio (OR) = 1.03, 95% confidence interval (95%CI): 0.95–1.12], TT vs CC (OR = 1.10, 95%CI: 0.91–1.33), CT vs CC (OR = 1.03, 95%CI: 0.91–1.16), CT/TT vs CC (OR = 1.04, 95%CI : 0.93–1.17), and TT vs. CC/CT (OR = 1.01, 95%CI : 0.78–1.31). In stratified analysis, however, we found a significant association between GNB3 C825T and increased breast cancer risk in Caucasian (TT vs CC OR=1.44, 95% CI=1.02–2.04; TT vs CT/CC OR=1.49, 95% CI=1.07–2.09).
Conclusion: The GNB3 C825T polymorphism was not associated with the risk of cancers as a whole, but there was a significant association between the polymorphism and breast cancer in Caucasian.

Keywords: Cancer, GNB3, C825T, Meta-analysis, Polymorphism

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Author Contributions:
Yaxuan Zhang – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Dongfeng Han – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Wenjin Wei – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Xiupeng Xu – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article
Rui Zhang – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the articles
Qingsheng Dong – Conception and design, Drafting the article, Critical revision of the article, Final approval of the version to be published
Xiefeng Wang – Conception and design, Drafting the article, Critical revision of the article, Final approval of the version to be published
Junxia Zhang – Conception and design, Drafting the article, Critical revision of the article, Final approval of the version to be published
Yingyi Wang – Conception and design, Drafting the article, Critical revision of the article, Final approval of the version to be published
Ning Liu – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Yaxuan Zhang et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.





About The Authors

Yaxuan Zhang is a postgraduate at neurosurgery of The First Affiliated Hospital of Nanjing Medical University. He earned undergraduate degree from Shanxi Medical University.



Dongfeng Han is Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China



Wenjin Wei is Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China



Xiupeng Xu is Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China



Rui Zhang is Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China



Qingsheng Dong is Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China



Xiefeng Wang is Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China



Junxia Zhang is Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China



Yingyi Wang is Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China



Ning Liu is Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China


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